HbA1c and interference due to hemoglobin disorders
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Spuriously Elevated HbA1c Result
Glycosylated haemoglobin (HbA1c) is routinely used test to monitor long term glycaemic control in diabetic patients. It is well known that genetic variants and chemically modified derivatives of haemoglobin can profoundly affect the accuracy of HbA1c measurements. The degree of interference depends on the HbA1c assay method, type & quantum of haemoglobin variant present in a given sample. Here,...
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Background & Objective: Diabetic hyperglycemia is associated with increased production of Reactive Oxygen Species (ROS). ROS reacts with DNA results in products such as 8-hydroxydeoxyguanosine that excrete in urine due to DNA repair processes. This study aims to evaluate correlation between oxidative damage of DNA and protein glycation in patients with Type 1 diabetes. We measured urinary 8-O...
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Diabetes Mellitus (DM) is the most common disorder of carbohydrate metabolism. Hyperglycemia is the common feature of DM. Hyperglycemia causes cardiovascular, renal, ocular, and peripheral nerve disorders in patients with diabetes. Glycemic regulation plays an essential role in controlling these complications. Thus, evaluation of the glycemic control status is crucial in the management of DM. H...
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In this article, an interference caused by hemoglobin H (Hb H), during the measurement of hemoglobin A1c (HbA1c) with ion exchange high pressure liquid chromatography (HPLC) method, was presented in blood sample of a 20-year-old male patient. HbA1c measurement was performed with Agilent 1200 HPLC system using a commercial Recipe HbA1c ion-exchange column. Hemoglobin electrophoresis was performe...
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